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Critically ill COVID-19 associated trait genetics reveals CDK6 inhibitors as potential treatment

2021-05-20 genetic and genomic medicine Title + abstract only
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BackgroundDespite recent development of vaccines and monoclonal antibodies to prevent SARS-CoV-2 infection, treatment of critically ill COVID-19 patients remains an important goal. In principle, genome-wide association studies (GWAS) could shortcut the clinical evidence needed to repurpose drugs - the use of an existing drug for a new indication. However, it has been shown that the genes found in GWA studies usually do not encode an established drug target and the causal role for disease, a key ...

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