Lack Of Association Between Convalescent Plasma Administration And Length Of Hospital Stay: A Hospital-Day Stratified Multi-Center Retrospective Cohort Study

BackgroundEffects of timing of Convalescent plasma (CP) administration on hospitalized COVID-19 patients are not established. MethodsWe used the National COVID Cohort Collaborative data to perform a retrospective cohort study of hospitalized COVID-19 patients in the United States between 07-01-2020 and 12-19-2020. We stratified patients based on day of CP administration (Day 0, 1, 2, 3 and 4) from COVID-19 diagnosis. We used 35 predictors to frame matched cohorts accounting for clinical and sociodemographic characteristics. We used competing risk survival models to examine the association between CP administration and length of hospital stay with in-hospital death as a competing risk performing Grays test on the cumulative incidence function and Coxs regression on cause specific hazard ratios. ResultsIn a cohort of 4,003 hospitalized COVID-19 patients, 197 (4.9%) received CP within the first 5 days following COVID-19 diagnosis. After adjusting for potential confounding variables, there were no statistically significant associations between day of CP administration and length of hospital stay. Day 0 CP administration signallled lower mortality but was not statistically significant (HR 0.45 [0.19-1.03]). ConclusionsWe found no association between the timing of CP administration and length of stay among hospitalized COVID-19 patients.