Distribution of GOPC:ROS1 and other ROS1 fusions in glioma types
Sievers, P.; Stichel, D.; Sill, M.; Schrimpf, D.; Sturm, D.; Selt, F.; Ecker, J.; Miele, E.; Kranendonk, M. E. G.; Tops, B. B. J.; Kohlhof-Meinecke, P.; Beschorner, R.; Kramm, C. M.; Hasselblatt, M.; Reifenberger, G.; Capper, D.; Wesseling, P.; Milde, T.; Korshunov, A.; Witt, O.; Pfister, S. M.; Wick, W.; von Deimling, A.; Jones, D. T. W.; Sahm, F.
Show abstract
The ROS proto-oncogene 1 (ROS1) gene is rearranged in various cancers. The translated fusion protein presents an attractive therapeutic target, since specific inhibitors have been approved for several tumor types. In glioma, ROS1 fusions are frequent within infantile hemispheric glioma, and single case reports on occurrences in other glioma types exist. However, a comprehensive analysis spanning the full width of glioma types and subtypes is lacking. We here assessed the spectrum and distribution of ROS1 fusions by screening >20,000 glioma cases for typical chromosomal alterations, with subsequent RNA-sequencing for confirmation of candidate cases. ROS1 fusions were identified in 16 cases, from low grade pilocytic astrocytoma WHO grade 1 to glioblastoma, IDH wildtype WHO grade 4. Thus, despite being enriched in some tumor types, ROS1 fusions are not pathognomonic for specific glioma types and may consitute a relevant target in a variety of cases.
Matching journals
The top 4 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- A subset of pediatric thalamic gliomas share a distinct DNA methylation profile, H3K27me3 loss and frequent alteration of EGFR 98%
- Pediatric High Grade Glioma Resources From the Children’s Brain Tumor Tissue Consortium (CBTTC) and Pediatric Brain Tumor Atlas (PBTA) 94%
- The impact of germline variants in DNA repair pathways on survival and temozolomide toxicity in adults with glioma 94%
Similar papers in this journal
- Tumor Mutational Burden Predicts Survival In Patients With Low Grade Gliomas Expressing Mutated IDH1 94%
- Tumor Edge-to-Core Transition Promotes Malignancy in Primary-to-Recurrent Glioblastoma Progression in a PLAGL1/CD109-mediated mechanism 92%
- Single-nucleus analysis characterizes non-enhancing region of recurrent high-grade glioma 92%
Similar papers in this journal
- Increased mRNA expression of CDKN2A is a transcriptomic marker of clinically aggressive meningiomas 93%
- Epigenetic landscape reorganization and reactivation of embryonic development genes are associated with malignancy in IDH-mutant astrocytoma 93%
- Primary and recurrent glioma patient-derived orthotopic xenografts (PDOX) represent relevant patient avatars for precision medicine 90%
Similar papers in this journal
- CD8+ T-cell-mediated immunoediting influences genomic evolution and immune evasion in murine gliomas 93%
- Remote Neuroinflammation in Newly Diagnosed Glioblastoma Correlates with Unfavorable Clinical Outcome 91%
- Preclinical modeling of surgery and steroid therapy for glioblastoma reveals changes in immunophenotype that are associated with tumor growth and outcome 90%
Similar papers in this journal
- Rapid DNA methylation-based classification of pediatric brain tumours from ultrasonic aspirate specimens 92%
- High Frequency and Unique Subtypes of Meningioma in Patients with BAP1 Tumor Predisposition Syndrome 91%
- Leveraging Single-Cell Sequencing to Classify and Characterize Tumor Subgroups in Bulk RNA-Sequencing Data 91%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.