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Optofluidic Fiber Component for Separation and counting of Micron-Sized Particles

Kumar, T.; Achar Vasant, H.; Etcheverry, S.; Margulis, W.; Laurell, F.; Russom, A.

2021-04-14 bioengineering
10.1101/2021.04.13.439593 bioRxiv
Show abstract

An all-fiber separation component capable of sorting and counting micron-sized particles based on size is presented. A sequence of silica fiber capillaries with various diameters and longitudinal cavities were used to fabricate the component for separation and detection in an uninterrupted flow. Fluorescence microparticles of 1 m and 10 m sizes are mixed in a visco-elastic fluid and infused into the all-fiber separation component. Elasto-inertial forces focus the larger particle to the center of the silica capillary, while the smaller microparticles exit from a side capillary. Analysis of the separated particles at the output showed a separation efficiency of 100% for the 10 m and 97% for the 1 m particles. In addition, the counting of the larger particles is demonstrated in the same flow. The separated 10 m particles are further routed through another all-fiber component for counting. A counting speed of ~1400 particles/min and with the variation in amplitude of 10% is achived. A combination of separation and counting can be powerful tool may find several applications in biology and medicine, such as separation and analysis of exosomes, bacteria, and blood cell sub-populations.

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