The Addiction Genetic Factor a(g): A Unitary Genetic Vulnerability Characterizes Substance Use Disorders and Their Associations with Common Correlates

2021-01-28 addiction medicine Title + abstract only

Show abstract

Substance use disorders commonly co-occur with one another and with other psychiatric disorders. They share common features including high impulsivity, negative affect, and lower executive function. We tested whether a common genetic factor undergirds liability to problematic alcohol use (PAU), problematic tobacco use (PTU), cannabis use disorder (CUD), and opioid use disorder (OUD) by applying genomic structural equation modelling to genome-wide association study summary statistics for individu...