Conserved Architecture of Brain Transcriptome Changes between Alzheimer's Disease and Progressive Supranuclear Palsy in Pathologically Affected and Unaffected Regions
Wang, X.; Allen, M.; Reddy, J. S.; Carrasquillo, M. M.; Asmann, Y. W.; Funk, C.; Nguyen, T. T.; Malphrus, K. G.; Younkin, S. G.; Dickson, D. W.; Price, N.; Golde, T. E.; Ertekin-Taner, N.
Show abstract
We identify a striking correlation in the directionality and magnitude of gene expression changes in brain transcriptomes between Alzheimers disease (AD) and Progressive Supranuclear Palsy (PSP). Further, the transcriptome architecture in AD and PSP is highly conserved between the temporal and cerebellar cortices, indicating highly similar transcriptional changes occur in pathologically affected and "unaffected" areas of the brain. These data have broad implications for interpreting transcriptomic data in neurodegenerative disorders.
Matching journals
The top 8 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- Dysregulated coordination of MAPT exon 2 and exon 10 splicing underlies different tau pathologies in PSP and AD 96%
- Genome-wide association study and functional validation implicates JADE1 in tauopathy 95%
- Essential tremor with tau pathology features seeds indistinguishable in conformation from Alzheimer's disease and primary age-related tauopathy 95%
Similar papers in this journal
- Regional interneuron transcriptional changes reveal pathologic markers of disease progression in a mouse model of Alzheimer's disease 97%
- Non-linear microglial, inflammatory and oligodendrocyte dynamics across stages of Alzheimer's disease 94%
- An interim exploratory biomarker analysis of a Phase 2 clinical trial to assess the impact of CT1812 in Alzheimers disease 94%
Similar papers in this journal
- Deciphering cellular transcriptional alterations in Alzheimer's disease brains 97%
- Genetic perturbations of disease risk genes in mice capture transcriptomic signatures of late-onset Alzheimer’s disease 95%
- Probe-dependent Proximity Profiling (ProPPr) Uncovers Similarities and Differences in Phospho-Tau-Associated Proteomes Between Tauopathies 94%
Similar papers in this journal
- Caspase-6-cleaved tau is relevant in Alzheimer’s disease but not in other tauopathies: diagnostic and therapeutic implications 95%
- Concurrent tau pathologies in frontotemporal lobar degeneration with TDP-43 pathology 93%
- Transcriptional Signatures of Synaptic Vesicle Genes Define Myotonic Dystrophy Type I Neurodegeneration 93%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.