Pharmacokinetics Of Transbuccal Swab-Administered Naloxone-Hcl Using A Novel Plant-Based Resin Formulation In Dogs
Johnson, R. M.; Azimi, N. T.; Schnipper, E. F.
Show abstract
A proof-of-concept transbuccal swab delivery of naloxone-HCL study using a mucoadhesive, plant-based film-forming resin formulation demonstrated comparable blood levels to benchmark intramuscular (IM) injection in highly predictive dog model. Results from this study allow the potential to translate rapid onset in humans with therapeutic blood levels being reached in 2-3 minutes comparable to that observed with commercially available parenteral injections and intranasal administrations. The simplicity, ease of delivery and rapid effectiveness has the potential to meet the public health emergency needs in the rescue of opioid overdosing.
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