Genetic maternal effects contributes to the risk of Tourette's disorder
Mahjani, B.; Klei, L.; Hultman, C. M.; Larsson, H.; Sandin, S.; Devlin, B.; Buxbaum, J.; Grice, D. E.
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BackgroundRisk for Tourettes and related tic disorders (CTD) derives from a combination of genetic and environmental factors. While multiple studies have demonstrated the importance of direct additive genetic variation for CTD, little is known about the role of cross-generational transmission of genetic risks, such as maternal effects. Here, we partition sources of variation on CTD risk into direct additive genetic effect and maternal effects. MethodsThe study population consists of 2,522,677 individuals from the Swedish Medical Birth Register, born in Sweden between January 1, 1982, to December 31, 1990, and followed for a diagnosis of CTD through December 31, 2013. ResultsWe identified 6,227 (0.25%) individuals in the birth cohort diagnosed with CTD. Using generalized linear mixed models, we estimated 4.7% (95% CrI, 4.4%-4.8%) genetic maternal effects, 0.5% (95% CrI, 0.2%-7%) environmental maternal effects, and 61% (95% CrI, 59%-63%) direct additive genetic effects. Around 1% of genetic maternal effects were due to maternal effects from the individual with comorbid obsessive-compulsive disorder. ConclusionsOur results demonstrate genetic maternal effects contributing to the risk of CTD in offspring and also highlight new sources of overlapping risk between CTD and obsessive-compulsive disorder.
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