A putative erm gene is present in ΔermB Clostridioides difficile isolates showing high levels of resistance to clindamycin
Ramirez Hernandez, V.; Ramirez Vargas, G.
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Clostridioides difficile has become the leading cause of hospital-acquired diarrhea. Clindamycin is a member of the macrolide-lincosamide-streptogramin B family of protein synthesis inhibitors. Been the ribosomal methylation the most widespread mechanism of resistance to these antibiotics in C difficile erm genes usually produce high levels of resistance to these drugs. In this short report we present evidence about the presence of an unreported putative erm gene in C difficile isolates that despite of presenting a {Delta}ermB genotype maintain high levels of clindamycin resistance.
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