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Bell-shaped dose response for a system with no IFFLs

Sontag, E.

2020-11-20 systems biology
10.1101/2020.11.17.387605 bioRxiv
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It is well known that the presence of an incoherent feedforward loop (IFFL) in a network may give rise to a steady state non-monotonic dose response. This note shows that the converse implication does not hold. It gives an example of a three-dimensional system that has no IFFLs, yet its dose response is bell-shaped. It also studies under what conditions the result is true for two-dimensional systems, in the process recovering, in far more generality, a result given in the T-cell activation literature.

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