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Algorithmic and data modeling: will algorithmic modeling improve predictions of traits evaluated on ordinal scales?

Xu, Z.; Kurek, A.; Cannon, S.; Beavis, W. D.

2020-10-07 genomics
10.1101/2020.10.07.329466 bioRxiv
Show abstract

Selection of markers linked to alleles at quantitative trait loci (QTL) for tolerance to Iron Deficiency Chlorosis (IDC) has not been successful. Genomic selection has been advocated for continuous numeric traits such as yield and plant height. For ordinal data types such as IDC, genomic prediction models have not been systematically compared. The objectives of research reported in this manuscript were to evaluate the most commonly used genomic prediction method, ridge regression and its equivalent logistic ridge regression method, with algorithmic modeling methods including random forest, gradient boosting, support vector machine, K-nearest neighbors, Naive Bayes, and artificial neural network using the usual comparator metric of prediction accuracy. In addition we compared the methods using metrics of greater importance for decisions about selecting and culling lines for use in variety development and genetic improvement projects. These metrics include specificity, sensitivity, precision, decision accuracy, and area under the receiver operating characteristic curve. We found that Support Vector Machine provided the best specificity for culling IDC susceptible lines, while Random Forest GP models provided the best combined set of decision metrics for retaining IDC tolerant and culling IDC susceptible lines.

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