Variability of Salivary and Nasal Specimens for SARS-CoV-2 Detection
Manabe, Y. C.; Reuland, C.; Yu, T.; Azamfirei, R.; Church, T.; Brown, D. M.; Sewell, T. T.; Hardick, J. P.; Blair, P. W.; Heaney, C. D.; Pekosz, A.; Thomas, D. L.
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In a large cohort of ambulatory confirmed COVID-19 patients with multiple self-collected sample time points, we compared 202 matched nasal-oropharyngeal swabs and oral salivary fluid sample pairs by RT-PCR. Nasal-oropharyngeal swabs were more sensitive than this salivary sample type (oral crevicular fluid) suggesting that not all saliva sample types have equivalent sensitivity. However, all samples that were Vero E6-TMPRSS2 cell culture positive (e.g., infectious virus) were also oral fluid RT-PCR positive suggesting that oral fluid may find the patients most likely to transmit disease to others.
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