Rapid detection of SARS-CoV2 by Ambient Mass Spectrometry Techniques
Ford, L. L.; Simon, D.; Balog, J.; Jiwa, N.; Higginson, J.; Jones, E.; Manoli, E.; Mason, S.; Wu, V.; Stavrakaki, S.; McKenzie, J.; McGill, D.; Koguna, H.; Kinross, J.; Takats, Z.
Show abstract
Ambient Ionisation Mass Spectrometry techniques: Desorption Electrospray Ionisation (DESI) and Laser Desorption - Rapid Evaporative Ionisation Mass Spectrometry (LD-REIMS) were used to detect the SARS-CoV-2 in dry nasal swabs. 45 patients were studied from samples collected between April - June 2020 in a clinical feasibility study. Diagnostic accuracy was calculated as 86.7% and 84% for DESI and LD-REIMS respectively. Results can be acquired in seconds providing robust and quick analysis of COVID-19 status which could be carried out without the need for a centralised laboratory. This technology has the potential to provide an alternative to population testing and enable the track and trace objectives set by governments and curtail the effects of a second surge in COVID-19 positive cases. In contrast to current PCR testing, using this technique there is no requirement of specific reagents which can cause devastating delays upon breakdowns of supply chains, thus providing a promising alternative testing method.
Matching journals
The top 5 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- Parallelized Acquisition of Orbitrap and Astral Analyzers Enables High-Throughput Quantitative Analysis. 96%
- Novel Real-Time Library Search driven data acquisition strategy for identification and characterization of metabolites. 96%
- Rapid Screening of COVID-19 Disease Directly from Clinical Nasopharyngeal Swabs using the MasSpec Pen Technology 96%
Similar papers in this journal
- Development of a Rapid and Specific MALDI-TOF Mass Spectrometric Assay for SARS-CoV-2 Detection 96%
- Moving translational mass spectrometry imaging towards transparent and reproducible data analyses: A case study of an urothelial cancer cohort analyzed in the Galaxy framework 94%
- A rigorous evaluation of optimal peptide targets for MS-based clinical diagnostics of Coronavirus Disease 2019 (COVID-19) 93%
Similar papers in this journal
Similar papers in this journal
- The challenge of structural heterogeneity in the native mass spectrometry studies of the SARS-CoV-2 spike protein interactions with its host cell-surface receptor 94%
- Development, validation and application of an LC-MS/MS method quantifying free forms of the micronutrients queuine and queuosine in human plasma using a surrogate matrix approach 93%
- Light contamination in stable isotope-labelled internal peptide standards is frequent and a potential source of false discovery and quantitation error in proteomics 93%
Similar papers in this journal
- Heterogeneous multimeric metabolite ion species observed in LC-MS based metabolomics data sets 95%
- Native Triboelectric Nanogenerator Ion Mobility-Mass Spectrometry of Egg Proteins Relevant to Objects of Cultural Heritage at Picoliter and Nanomolar Quantities. 94%
- RP-UHPLC/MS/MS Provides Enhanced Lipidomic Profiling of Human Serum in Pancreatic Cancer 93%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.