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Robust Self-Regeneratable Stiff Living Materials

Manjula-Basavanna, A.; Duraj-Thatte, A.; Joshi, N. S.

2020-09-25 synthetic biology
10.1101/2020.09.24.311589 bioRxiv
Show abstract

Living systems have not only the exemplary capability to fabricate materials (e.g. wood, bone) under ambient conditions but they also consist of living cells that imbue them with properties like growth and self-regeneration. Like a seed that can grow into a sturdy living wood, we wondered: can living cells alone serve as the primary building block to fabricate stiff materials? Here we report the fabrication of stiff living materials (SLMs) produced entirely from microbial cells, without the incorporation of any structural biopolymers (e.g. cellulose, chitin, collagen) or biominerals (e.g. hydroxyapatite, calcium carbonate) that are known to impart stiffness to biological materials. Remarkably, SLMs are also lightweight, strong, resistant to organic solvents and can self-regenerate. This living materials technology can serve as a powerful biomanufacturing platform to design and develop sustainable structural materials, biosensors, self-regulators, self-healing and environment-responsive smart materials.

Matching journals

The top 8 journals account for 50% of the predicted probability mass.

1
Advanced Materials
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Top 0.1%
11.2%
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2
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10.0%
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3
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5.9%
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5
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○ 28 papers in training set
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6
Science Advances
● 1243 papers in training set
Top 6%
4.5%
7
ACS Applied Materials & Interfaces
● 39 papers in training set
Top 0.2%
3.8%
8
Proceedings of the National Academy of Sciences
● 2444 papers in training set
Top 14%
3.8%
50% of probability mass above
9
ACS Synthetic Biology
● 287 papers in training set
Top 0.8%
3.8%
10
Advanced Healthcare Materials
○ 85 papers in training set
Top 0.6%
3.3%
11
ChemBioChem
○ 55 papers in training set
Top 0.4%
3.0%
12
ACS Applied Bio Materials
● 24 papers in training set
Top 0.2%
3.0%
13
Small
○ 78 papers in training set
Top 0.5%
3.0%
14
Materials Today Bio
○ 20 papers in training set
Top 0.2%
3.0%
15
Acta Biomaterialia
○ 92 papers in training set
Top 0.5%
3.0%
16
Advanced Science
○ 286 papers in training set
Top 3%
2.6%
17
Biomaterials Advances
○ 22 papers in training set
Top 0.2%
2.5%
18
Advanced Functional Materials
○ 46 papers in training set
Top 0.6%
2.3%
19
Soft Matter
● 60 papers in training set
Top 0.3%
2.3%
20
Communications Chemistry
○ 48 papers in training set
Top 0.4%
2.0%
21
Advanced Materials Technologies
○ 29 papers in training set
Top 0.3%
1.6%
22
Journal of the American Chemical Society
● 217 papers in training set
Top 2%
1.6%
23
Biomacromolecules
● 29 papers in training set
Top 0.3%
1.6%
24
ACS Biomaterials Science & Engineering
● 37 papers in training set
Top 0.6%
1.3%
25
Angewandte Chemie International Edition
○ 93 papers in training set
Top 1%
1.0%
26
ACS Omega
● 105 papers in training set
Top 4%
0.8%
27
iScience
○ 1154 papers in training set
Top 43%
0.6%

"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.