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Human essentiality genes and targeted oncology therapies

Harper, A. R.; McDermott, U.; Petrovski, S.

2020-08-18 genomics
10.1101/2020.08.18.256198 bioRxiv
Show abstract

Human essentiality genes are significantly enriched in targeted therapies successfully used in oncology. Embedding human essentiality metrics into discovery pipelines could optimise the delivery of highly effective targeted therapies among clinical development strategies.

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