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DNA methylation signatures of C-reactive protein associations with structural neuroimaging measures and major depressive disorder
2020-08-17
psychiatry and clinical psychology
Title + abstract only
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BackgroundInflammatory processes are implicated in the aetiology of Major Depressive Disorder (MDD); however, the relationship between peripheral inflammation, brain structure and depression remains unclear. This study investigates associations between depression, structural neuroimaging measures and two measures of inflammation: serum-based C-reactive protein (CRP) and a methylation-based score for CRP (DNAm CRP) in a large community-based sample. MethodsSerum CRP and DNAm CRP were assessed fo...
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