Histopathology of Third Trimester Placenta from SARS-CoV-2-Positive Women
He, M.; Skaria, P.; Kreutz, K.; Chen, L.; Hagemann, I.; Carter, E. B.; Mysorekar, I. U.; Nelson, D. M.; Pfeifer, J.; Dehner, L. P.
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BackgroundThis study aims to investigate whether maternal SARS-CoV-2 status affect placental pathology. MethodsA retrospective case-control study was conducted by reviewing charts and slides of placentas between April 1 to July 24, 2020. Clinical history of "COVID-19" were searched in Pathology Database (CoPath). Controls were matched with SARS-CoV-2-negative women with singleton deliveries in the 3rd-trimester. Individual and group, pathological features were extracted from placental pathology reports. ResultsTwenty-one 3rd-trimester, placentas from SARS-CoV-2-positive women were identified and compared to 20 placentas from SARS-CoV-2-negative women. There were no significant differences in individual or group gross or microscopic pathological features between the groups. Within the SARS-CoV-2+ group, there are no differences between symptomatic and asymptomatic women. ConclusionPlacentas from SARS-CoV-2-positive women do not demonstrate a specific pathological pattern. Pregnancy complicated with COVID-19 during the 3rd trimester does not have a demonstrable effect on placental structure and pathology.
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