Back

Using Real-World Data to Rationalize Clinical Trials Eligibility Criteria Design: A Case Study of Alzheimer's Disease Trials

2020-08-04 health informatics Title + abstract only
View on medRxiv
Show abstract

Low trial generalizability is a concern. The Food and Drug Administration had guidance on broadening trial eligibility criteria to enroll underrepresented populations. However, investigators are hesitant to do so because of concerns over patient safety. There is a lack of methods to rationalize criteria design. In this study, we used data from a large research network to assess how adjustments of eligibility criteria can jointly affect generalizability and patient safety (i.e the number of serio...

Predicted journal destinations

1
BMC Medical Research Methodology
41 training papers
#1 10.6%
2
Journal of the American Medical Informatics Association
53 training papers
Top 2% 8.7%
3
JAMIA Open
35 training papers
Top 2% 6.2%
4
PLOS ONE
1737 training papers
Top 74% 6.2%
5
npj Digital Medicine
85 training papers
Top 4% 6.2%
6
Scientific Reports
701 training papers
Top 49% 5.7%
7
Journal of Medical Internet Research
81 training papers
Top 4% 4.8%
8
Journal of Biomedical Informatics
37 training papers
Top 3% 4.8%
9
PLOS Digital Health
88 training papers
Top 6% 4.0%
10
BMC Medical Informatics and Decision Making
36 training papers
Top 4% 4.0%
11
Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring
28 training papers
Top 2% 2.7%
12
Journal of Alzheimer’s Disease
23 training papers
Top 0.7% 2.7%
13
International Journal of Medical Informatics
25 training papers
Top 4% 1.9%
14
BMJ Open
553 training papers
Top 50% 1.9%
15
JMIR Medical Informatics
16 training papers
Top 3% 1.9%
16
Nature Communications
483 training papers
Top 44% 1.5%
17
Computers in Biology and Medicine
39 training papers
Top 6% 1.3%
18
Frontiers in Digital Health
18 training papers
Top 1% 1.3%
19
Alzheimer's & Dementia
84 training papers
Top 7% 1.1%
20
JAMA Network Open
125 training papers
Top 20% 1.1%
21
JMIR Formative Research
31 training papers
Top 5% 0.9%
22
Frontiers in Neurology
74 training papers
Top 12% 0.9%
23
Patterns
15 training papers
Top 3% 0.9%
24
Communications Medicine
63 training papers
Top 5% 0.9%
25
GeroScience
22 training papers
Top 2% 0.9%
26
Journal of Alzheimer's Disease
31 training papers
Top 5% 0.9%
27
Journal of Clinical Epidemiology
29 training papers
Top 2% 0.9%
28
Journal of Allergy and Clinical Immunology
15 training papers
Top 2% 0.7%
29
iScience
74 training papers
Top 14% 0.7%
30
JMIR Public Health and Surveillance
45 training papers
Top 11% 0.7%