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Cell-to-cell Mathematical Modeling of Arrhythmia Phenomena in the Heart

Lopez, G.; Nicolas, A.; Roman, G.; Godinez, R.; Castro, M. A.

2020-07-29 biophysics
10.1101/2020.07.28.225755 bioRxiv
Show abstract

With an aperiodic, self-similar distribution of two-dimensional arrangement of atrial cells, it is possible to simulate such phenomena as Fibrillation, Fluttering, and a sequence of Fibrillation-Fluttering. The topology of a network of cells may facilitate the initiation and development of arrhythmias such as Fluttering and Fibrillation. Using a GPU parallel architecture, two basic cell topologies were considered in this simulation, an aperiodic, fractal distribution of connections among 462 cells, and a chessboard-like geometry of 60x60 and 600x600 cells. With a complex set of initial conditions, it is possible to produce tissue behavior that may be identified with arrhythmias. Finally, we found several sets of initial conditions that show how a mesh of cells may exhibit Fibrillation that evolves into Fluttering.

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