Determinants of quality of life in Latin American people with drug-resistant epilepsy: A cross-sectional, correlational study
Diaz-Torres, M. A.; Buzo-Jarquin, E. G.; Rodriguez-Martinez, A. C.; de Leon-Altamira, D. L.; Padilla-Rivas, G.; Castillo-Torres, S. A.; Olivas-Reyes, J. E. G.; Cisneros-Franco, M.
Show abstract
One third of people with epilepsy (PWE) continue to have seizures despite adequate antiepileptic drug treatment. This condition, known as drug-resistant epilepsy (DRE) significantly impairs their social, family and work environment. The aims of this study were to assess the quality of life (QoL) in PWE with DRE and to investigate which factors are associated with a better QoL. This was a cross-sectional observational study of 133 Latin American PWE. QoL was assessed with the Spanish version of the Quality of Life with Epilepsy questionnaire (QOLIE-10). Independent clinical variables were analyzed with non-parametric statistics and their association with QoL was investigated with multiple linear regression. Poor quality of life was found in 25.8% of PWE. A low number of antiepileptic drugs (AEDs) was the major factor associated with better quality of life, closely followed by seizure frequency. We conclude that careful selection of AED treatment may contribute to improving both seizure control and QoL.
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