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Incidence of COVID-19 and Connections with Air Pollution Exposure: Evidence from the Netherlands

Andree, B. P. J.

2020-05-03 epidemiology
10.1101/2020.04.27.20081562
Show abstract

The fast spread of severe acute respiratory syndrome coronavirus 2 has resulted in the emergence of several hot-spots around the world. Several of these are located in areas associated with high levels of air pollution. This study investigates the relationship between exposure to particulate matter and COVID-19 incidence in 355 municipalities in the Netherlands. The results show that atmospheric particulate matter with diameter less than 2.5 is a highly significant predictor of the number of confirmed COVID-19 cases and related hospital admissions. The estimates suggest that expected COVID-19 cases increase by nearly 100 percent when pollution concentrations increase by 20 percent. The association between air pollution and case incidence is robust in the presence of data on health-related preconditions, proxies for symptom severity, and demographic control variables. The results are obtained with ground-measurements and satellite-derived measures of atmospheric particulate matter as well as COVID-19 data from alternative dates. The findings call for further investigation into the association between air pollution and SARS-CoV-2 infection risk. If particulate matter plays a significant role in COVID-19 incidence, it has strong implications for the mitigation strategies required to prevent spreading. HighlightsO_ST_ABSBackgroundC_ST_ABSResearch on viral respiratory infections has found that infection risks increase following exposure to high concentrations of particulate matter. Several hot-spots of Severe Acute Respiratory Syndrome Coronavirus 2 infections are in areas associated with high levels of air pollution. ApproachThis study investigates the relationship between exposure to particulate matter and COVID-19 incidence in 355 municipalities in the Netherlands using data on confirmed cases and hospital admissions coded by residence, along with local PM2.5, PM10, population density, demographics and health-related pre-conditions. The analysis utilizes different regression specifications that allow for spatial dependence, nonlinearity, alternative error distributions and outlier treatment. ResultsPM2.5 is a highly significant predictor of the number of confirmed COVID-19 cases and related hospital admissions. Taking the WHO guideline of 10mcg/m3 as a baseline, the estimates suggest that expected COVID-19 cases increase by nearly 100% when pollution concentrations increase by 20%. ConclusionThe findings call for further investigation into the association between air pollution on SARS-CoV-2 infection risk. If particulate matter plays a significant role in the incidence of COVID-19 disease, it has strong implications for the mitigation strategies required to prevent spreading, particularly in areas that have high levels of pollution.

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