COVID-19 Critical Illness Pathophysiology Driven by Diffuse Pulmonary Thrombi and Pulmonary Endothelial Dysfunction Responsive to Thrombolysis
Poor, H. D.; Ventetuolo, C. E.; Tolbert, T.; Chun, G.; Serrao, G.; Zeidman, A.; Dangayach, N. S.; Olin, J.; Kohli-Seth, R.; Powell, C. A.
Show abstract
Critically ill COVID-19 patients have relatively well-preserved lung mechanics despite severe gas exchange abnormalities, a feature not consistent with classical ARDS but more consistent with pulmonary vascular disease. Patients with severe COVID-19 also demonstrate markedly abnormal coagulation, with elevated D-dimers and higher rates of venous thromboembolism. We present four cases of patients with severe COVID-19 pneumonia with severe respiratory failure and shock who demonstrated immediate improvements in gas exchange and/or hemodynamics with systemic tPA. Subject category4.6 ICU Management and Outcome
Matching journals
The top 8 journals account for 50% of the predicted probability mass.