Back

Lipidated poly(amino acid) nanostructures as versatile therapeutic delivery vehicles

Smith, J. D.; Cardwell, L. N.; Porciani, D.; Greenwald, A. J.; Ellis, A. C.; Schulte, M. C.; Wang, X.; Schoenherr, E. T.; Seim, G. F.; Anderson, J. E.; Nguyen, J. A.; Tata, R. R.; Lange, M. J.; Burke, D. H.; Daniels, M. A.; Ulery, B. D.

2020-04-08 bioengineering
10.1101/2020.04.07.004333 bioRxiv
Show abstract

Poly(amino acid)s are a diverse and capable class of polymers with significant potential for utilization in a wide variety of drug delivery applications. A sub-class of these biomaterials known as lipidated poly(amino acid)s (LPAAs) are amphiphiles composed of both hydrophobic and hydrophilic domains yielding interesting physical properties. In this article, we describe our efforts in developing a novel class of lysine and valine containing LPAAs synthesized via hexadecylamine initiated N-carboxyanhydride ring-opening polymerization (NCA-ROP). These highly hydrophobic LPAAs were found capable of undergoing hydrophobically-driven self-assembly into small nanostructures as well as being forced into larger nanostructures using a novel dump-and-stir nanoprecipitation process. This process yielded fine control over resulting nanoparticle size and cargo entrapment. Furthermore, cell-targeting DNA aptamer modification of doxorubicin-loaded LPAA nanoparticles induced significant death of co-incubated Non-Hodgkin Lymphoma cells providing exciting evidence of the therapeutic potential of this novel biomaterials-based delivery device.

Matching journals

The top 9 journals account for 50% of the predicted probability mass.

1
ACS Applied Materials & Interfaces
● 39 papers in training set
Top 0.1%
10.8%
Similar papers in this journal
2
Biomacromolecules
● 29 papers in training set
Top 0.1%
7.1%
Similar papers in this journal
3
ACS Nano
● 113 papers in training set
Top 0.3%
6.6%
Similar papers in this journal
4
Journal of Controlled Release
○ 44 papers in training set
Top 0.2%
5.4%
Similar papers in this journal
5
ACS Biomaterials Science & Engineering
● 37 papers in training set
Top 0.2%
4.3%
Similar papers in this journal
6
Nanoscale
● 42 papers in training set
Top 0.1%
4.2%
7
Advanced Functional Materials
○ 46 papers in training set
Top 0.3%
4.2%
8
Bioconjugate Chemistry
● 20 papers in training set
Top 0.1%
4.0%
9
Nanoscale Advances
● 15 papers in training set
Top 0.1%
3.4%
50% of probability mass above
10
Langmuir
● 36 papers in training set
Top 0.2%
3.4%
11
ACS Applied Bio Materials
● 24 papers in training set
Top 0.1%
3.4%
12
Small
○ 78 papers in training set
Top 0.5%
3.2%
13
Biomaterials Science
● 24 papers in training set
Top 0.2%
3.2%
14
ACS Omega
● 105 papers in training set
Top 0.9%
2.4%
15
Nature Communications
○ 5641 papers in training set
Top 42%
2.1%
16
Advanced Healthcare Materials
○ 85 papers in training set
Top 0.9%
1.7%
17
Advanced Materials
○ 56 papers in training set
Top 0.7%
1.6%
18
Advanced Therapeutics
○ 17 papers in training set
Top 0.2%
1.5%
19
Scientific Reports
○ 3612 papers in training set
Top 65%
1.1%
20
Biomaterials
○ 84 papers in training set
Top 1%
1.1%
21
Science Advances
● 1243 papers in training set
Top 26%
1.1%
22
Advanced Science
○ 286 papers in training set
Top 7%
1.1%
23
Pharmaceutics
○ 24 papers in training set
Top 0.5%
1.1%
24
PLOS ONE
● 5266 papers in training set
Top 57%
1.0%
25
Communications Chemistry
○ 48 papers in training set
Top 1%
0.9%
26
Nano Letters
● 71 papers in training set
Top 1%
0.8%
27
Biomaterials Advances
○ 22 papers in training set
Top 0.6%
0.8%
28
Bioactive Materials
○ 20 papers in training set
Top 0.5%
0.8%
29
Molecules
○ 39 papers in training set
Top 2%
0.6%
30
Materials Today Bio
○ 20 papers in training set
Top 0.8%
0.6%

"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.