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Integration of urine proteomics and renal single-cell genomics identifies an interferon-gamma response gradient in lupus nephritis.
2020-03-17
rheumatology
Title + abstract only
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Lupus nephritis, one of the most serious manifestations of systemic lupus erythematosus (SLE), has both a heterogeneous clinical and pathological presentation. For example, proliferative nephritis identifies a more aggressive disease class that requires immunosuppression. However, the current classification system relies on the static appearance of histopathological morphology which does not capture differences in the inflammatory response. Therefore, a biomarker grounded in the disease biology ...
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