Back
Top 1%
11.6%
Top 0.5%
11.6%
#1
10.7%
Top 0.8%
7.6%
Top 0.3%
7.6%
Top 0.3%
5.8%
Top 3%
5.5%
Top 1%
4.9%
Top 4%
4.1%
Top 5%
3.1%
Top 3%
2.7%
Top 2%
1.9%
Top 1%
1.9%
Top 93%
1.9%
Top 38%
1.9%
Top 2%
1.5%
Top 0.9%
1.2%
Top 4%
1.2%
Top 3%
1.2%
Top 3%
0.9%
Top 93%
0.9%
Top 3%
0.7%
Top 4%
0.7%
Top 3%
0.7%
Top 10%
0.7%
Clinical Efficacy and Target Engagement of Glutamatergic Drugs: Placebo-Controlled RCTs of Pomaglumetad and TS-134 for Reversal of Ketamine-Induced Psychotic Symptoms and PharmacoBOLD in Healthy Volunteers
2020-03-12
psychiatry and clinical psychology
Title + abstract only
View on medRxiv
Show abstract
We tested two metabotropic glutamate receptor 2/3 (mGluR2/3) agonist prodrugs - pomaglumetad (POMA) and TS-134 - including a high-dose of POMA that was four times the dose tested in the failed phase schizophrenia III trials - in two proof of mechanism, Phase Ib studies using identical pharmacoBOLD target-engagement methodology. The POMA study was a double-blind, NIMH-sponsored, 10-day study of 80 or 320 mg/d POMA or placebo (1:1:1 ratio), designed to detect d>0.8 sd between-group effect-size di...
Predicted journal destinations
1
Translational Psychiatry
94 training papers
2
Molecular Psychiatry
84 training papers
3
Biological Psychiatry
36 training papers
4
Psychological Medicine
52 training papers
5
Schizophrenia Bulletin
21 training papers
6
Neuropsychopharmacology
29 training papers
7
Journal of Affective Disorders
72 training papers
8
Biological Psychiatry: Cognitive Neuroscience and Neuroimaging
27 training papers
9
Frontiers in Psychiatry
56 training papers
10
NeuroImage: Clinical
77 training papers
11
Psychiatry Research
33 training papers
12
Journal of Psychiatric Research
22 training papers
13
Biological Psychiatry Global Open Science
23 training papers
14
PLOS ONE
1737 training papers
15
Nature Communications
483 training papers
16
Brain, Behavior, and Immunity
35 training papers
17
American Journal of Medical Genetics Part B: Neuropsychiatric Genetics
15 training papers
18
BJPsych Open
24 training papers
19
The British Journal of Psychiatry
21 training papers
20
Neuroscience & Biobehavioral Reviews
19 training papers
21
Scientific Reports
701 training papers
22
Journal of Child Psychology and Psychiatry
18 training papers
23
BMC Psychiatry
20 training papers
24
BMJ Mental Health
15 training papers
25
Human Brain Mapping
53 training papers