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Tailored polymeric, photovoltaic, and near-infrared-responsive neuroprosthesis

Airaghi Leccardi, M. J.; Chenais, N. A.; Ferlauto, L.; Kawecki, M.; Zollinger, E. G.; Ghezzi, D.

2020-01-28 bioengineering
10.1101/2020.01.27.920819 bioRxiv
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Organic materials, such as conjugated polymers, are attractive building blocks for bioelectronic interfaces. In particular, organic semiconductors showed excellent performances in light-mediated excitation and silencing of neuronal cells and tissues. However, the main challenges of these organic photovoltaic interfaces compared to inorganic prostheses are the limited stability of conjugated polymers in the aqueous environment and the exploitation of materials only responsive in the visible spectrum. In this report, we show a new photovoltaic organic interface tailored for neuronal stimulation in the near-infrared spectrum. Also, we adjusted the organic materials by chemical modification in order to improve the stability in aqueous environment and to modulate the photoelectrical stimulation efficiency. As proof of principle, we tested this interface for retinal stimulation. Our results provide an efficient, reliable, and stable implant applicable for neural stimulation.

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