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Higher polygenic risk scores for schizophrenia may be suggestive of treatment non-response in major depressive disorder
2020-01-18
psychiatry and clinical psychology
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BackgroundUp to 60% of patients with major depressive disorder (MDD) do not respond to the first treatment with antidepressants. Response to antidepressants is a polygenic trait, although its underpinning genetics has not been fully clarified. This study aimed to investigate if Polygenic Risk Scores (PRSs) for major psychiatric disorders and neuroticism were associated with non-response or resistance to antidepressants in MDD. MethodsPRSs for bipolar disorder, MDD, neuroticism, and schizophreni...
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