Work horse strain Clostridioides difficile 630Δerm is oblivious to its anaerobic lifestyle
Troitzsch, D.; Zhang, H.; Dittmann, S.; Düsterhöft, D.; Michel, A.-M.; Jänsch, L.; Riedel, K.; Borrero-de Acuna, J. M.; Jahn, D.; Sievers, S.
Show abstract
The laboratory reference strain 630{Delta}erm of the anaerobic human pathogen Clostridioides difficile is characterized by a remarkable high oxygen tolerance. We show that an amino acid exchange in the DNA binding domain of the hydrogen peroxide sensor PerR results in a constitutive derepression of PerR-controlled genes and thus in an oxidative stress response even under anaerobic conditions. This questions the model status, strain 630{Delta}erm claims in C. difficile research.
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