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Optimization and functionalization of red-shifted rhodamine dyes

Grimm, J. B.; Tkachuk, A. N.; Choi, H.; Mohar, B.; Falco, N.; Patel, R.; Lippincott-Schwartz, J.; Brown, T. A.; Lavis, L. D.

2019-12-20 cell biology
10.1101/2019.12.20.881227 bioRxiv
Show abstract

Expanding the palette of fluorescent dyes is vital for pushing the frontier of biological imaging. Although rhodamine dyes remain the premier type of small-molecule fluorophore due to their bioavailability and brightness, variants excited with far-red or near-infrared light suffer from poor performance due to their propensity to adopt a lipophilic, nonfluorescent form. We report a general chemical modification for rhodamines that optimizes long-wavelength variants and enables facile functionalization with different chemical groups.

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