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Individual differences in the course of youth depression: The importance of renitence and reversion

Hawrilenko, M.; Masyn, K. E.; Cerutti, J. K.; Dunn, E. C.

2019-11-27 psychiatry and clinical psychology
10.1101/19012872 medRxiv
Show abstract

Studies of developmental trajectories of depression are important for understanding its etiology. Existing studies have been limited by short time frames and no studies have explored a key factor: differential patterns of responding to life events. This paper introduces a novel analytic technique, growth mixture modeling with structured residuals, to examine the course of youth depression symptoms in a large, prospective cohort (N=11,641, ages 4-16.5). Age-specific critical points were identified at ages 10 and 13 where depression symptoms spiked for a minority of children. However, most depression risk was due to dynamic responses to environmental events, drawn not from a small pool of persistently depressed children, but a larger pool of children who varied across higher and lower symptom levels.

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