Back

Implications of MGMT promoter methylation and its downstream hMSH2 mRNA in primary malignant glioma

2019-10-18 oncology Title + abstract only
View on medRxiv
Show abstract

BackgroundHypermethylation of 06-methylguanine DNA methyltransferase (MGMT)promoter seen in high grade gliomas (HGG) leads to the accumulation of O6-meG DNA damage which mispairs with thymine, requiring recognition by mismatch repair protein dimer MutS, whose primary component is coded by Human MutS homolog protein 2 (hMSH2). O6-meG repair necessitates the interaction/combined action of MGMT andhMSH2 to maintain genomic stability. Analysis of the correlation between MGMT methylation and hMSH2mRN...

Predicted journal destinations

1
Cancers
57 training papers
Top 1% 14.7%
2
Frontiers in Oncology
34 training papers
Top 0.4% 11.9%
3
PLOS ONE
1737 training papers
Top 72% 6.4%
4
Scientific Reports
701 training papers
Top 37% 6.4%
5
Aging
18 training papers
#1 6.0%
6
Clinical Cancer Research
22 training papers
Top 2% 5.6%
7
PeerJ
46 training papers
Top 0.2% 3.1%
8
Cancer Medicine
17 training papers
Top 2% 2.8%
9
International Journal of Molecular Sciences
39 training papers
Top 1% 1.9%
10
Frontiers in Genetics
32 training papers
Top 0.9% 1.9%
11
Computers in Biology and Medicine
39 training papers
Top 3% 1.9%
12
BMC Cancer
21 training papers
Top 2% 1.9%
13
British Journal of Cancer
22 training papers
Top 3% 1.9%
14
Clinical Epigenetics
21 training papers
Top 0.1% 1.9%
15
Nature Communications
483 training papers
Top 37% 1.9%
16
Frontiers in Pharmacology
27 training papers
Top 1% 1.6%
17
Frontiers in Immunology
140 training papers
Top 7% 1.6%
18
Frontiers in Neuroscience
29 training papers
Top 2% 1.6%
19
EBioMedicine
21 training papers
Top 0.1% 1.5%
20
eLife
262 training papers
Top 34% 1.3%
21
iScience
74 training papers
Top 8% 1.2%
22
Diagnostics
36 training papers
Top 3% 1.2%
23
Heliyon
57 training papers
Top 9% 1.0%
24
Communications Biology
36 training papers
Top 5% 0.7%
25
Proceedings of the National Academy of Sciences
100 training papers
Top 20% 0.7%
26
Cell Reports
25 training papers
Top 2% 0.7%
27
JAMA Network Open
125 training papers
Top 30% 0.7%